Optimizing Vancomycin dosing with Bayesian methods

Dose optimization and monitoring of medications are complex. Clinicians must evaluate and act on patient-specific factors that influence pharmacokinetics and pharmacodynamics. Sentri7® Pharmacy supports personalized vancomycin dosing and other medications to enhance patient safety and streamline pharmacy workflows.

Why Bayesian dosing?

Bayesian dosing uses patient data and laboratory results to estimate a patient's ability to absorb, process, and clear a drug from their system. Using a clinically validated population model, algorithms adjust the pharmacokinetic and/or pharmacodynamic parameters so that a patient-specific, individualized drug model is built. This individual model is then used to provide a patient-specific dosing recommendation to reach a therapeutic target.

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We're collaborating to optimize dosing

PrecisePK
PrecisePK 
PrecisePK and Sentri7 Pharmacy will offer an integrated Bayesian dosing solution in 2023. With PrecisePK’s industry-leading model-informed precision dosing (MIPD) software, Sentri7 Pharmacy will deliver a comprehensive drug package that supports vancomycin and 20+ other medications for oncology, neurology, cardiology, and additional antimicrobials. 
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DoseMeRx
DoseMeRx™
DoseMeRx precision dosing is currently integrated with Sentri7’s Antimicrobial Stewardship (AMS). With a single click, pharmacists review patient-specific parenteral vancomycin dose recommendations calculated automatically using key clinical data such as patient weight, laboratory values, creatinine levels, and drug administration times. 
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Enhance Bayesian Dosing with Sentri7 and precision dosing partners

Vancomycin is one of the most used antibiotics in hospitals today. Traditionally, calculating precise vancomycin doses for patients requires coordination among pharmacists, nurses, and phlebotomists, as well as manual data entry that is time-consuming and prone to errors. Integrated precisions dosing solutions with Sentri7 provide an easy path to implement ASHP’s 2020 recommendation for dosing and monitoring vancomycin. Here's what you can expect with our partners' Bayesian dosing solution integrations with Sentri7:

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Automated parenteral dose recommendations
Review patient-specific parenteral dose recommendations calculated automatically with a single click. 
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Evidence-based antimicrobial stewardship
Assess medication use and ensure prescribing is in line with AMS goals and the CDC’s Core Elements. 
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Proactive kidney injury monitoring
Proactively monitor for adjustments and reduce the risk of acute kidney injury (AKI) with dose recommendations. 
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Streamlined pharmacist workflow
Obtain dose recommendations in seconds by leveraging patient data pulled automatically from Sentri7. 
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Individualized dose calculation
Calculate individualized doses from as little as one vancomycin level with algorithms that account for variation. 
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Standardized care and compliance
Standardize care with data-driven dose optimization and increase proportion of patients in therapeutic range. 
Article
Santéfévrier 13, 2024
From burnout to balance: How Bayesian tools reshape pharmacy practice 
Par : Steve Mok, PharmD, MBA, BCPS, BCIDP
Bayesian dosing tools support pharmacy teams in optimizing workflows and redefining efficiencies.
En savoir plus
Webinar
Santéjuin 16, 2022
Webinar: Optimize your pharmacy workflow - a guide to implementing Bayesian dosing
Par : Steve Mok, PharmD, MBA, BCPS, BCIDP
In this webinar learn how to leverage tools to support Bayesian dosing and automate workflow, ensuring every patient receives an optimal dose to improve outcomes.
En savoir plus
Article
Santéaoût 16, 2021
Six benefits of integrating a Bayesian dosing calculator into your clinical surveillance technology
Par : Steve Mok, PharmD, MBA, BCPS, BCIDP
Clinical surveillance solutions, integrated with Bayesian dosing calculators, can facilitate optimal dosing recommendations for each patient by seamlessly pulling existing patient data.
En savoir plus
Back to AMS Basics
Practical and actionable resources to optimize your AMS program and prepare to meet accreditation and regulatory requirements. 
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