UpToDate Expert AI: Generative AI for doctors and medical professionals

Clinical decisions aren’t always black-and-white—and neither are clinical questions. UpToDate® Expert AI delivers fast, reliable answers through a conversational experience that feels like consulting a trusted colleague. Purpose-built for today’s clinicians, it combines the power of generative AI with rigorously vetted, expert-authored content from UpToDate —connecting users to the clinical intelligence needed to make confident, informed care decisions.

Now available in the new UpToDate Pro Plus package, UpToDate personal trainee subscriptions, and to select UpToDate Enterprise Edition accounts.

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UpToDate® Expert AI is generative AI built only on curated, evidence-based clinical content that delivers the nuance and context clinicians need for real-world care decisions.
  • GenAI with clinical oversight

  • Transparent reasoning

  • Tailored responses

Support safe care with the GenAI solution built by clinicians, for clinicians.

UpToDate Expert AI delivers trusted insights grounded in the evidence-based recommendations from over 7,600 clinicians, and built with rigorous AI standards that prioritize transparency, evidence, and clinical integrity. Every answer is traceable and includes direct links to UpToDate topics.

Features that connect responses to UpToDate content and clinical expertise:

  • Learn More offers suggested follow-up questions to guide deeper understanding.
  • UpToDate Sources provide clear sources and citations to the supporting UpToDate content.
 

Designed to support clinical reasoning, not replace it. 

Engage in interactive dialogue that delivers more than just insights. Every response from UpToDate Expert AI includes transparent reasoning and clearly stated assumptions, helping you understand not only the recommendations provided, but the rationale behind them.  

Features that promote transparency and clinical reasoning: 

  • Assumptions frame the question and clarify the clinical problem. 
  • Rationale explains the “why” behind each response. 
  • Thinking shows referenced UpToDate topics. 

Elevate your clinical decision making with tailored recommendations.

Get nuanced support for working through cases, interpreting evidence, and applying insights to patient care. Designed to think like a clinician, UpToDate Expert AI empowers your clinical judgment without replacing it. 

Features that support fast understanding and clinical decision making:

  • Considerations highlight important details and anticipate common missteps. 
  • Key Points provide relevant clinical considerations.  
  • Tailored visuals simplify complex clinical content.  

The latest insights on AI from UpToDate

“UpToDate Expert AI is a smarter, faster way to deliver trusted answers—right when clinicians need them. It’s a natural extension of how we deliver care: quick, reliable, and evidence-based.”
Charles J. Sonday, DNP
Associate Chief Medical Information Officer
St. Luke’s University Health Network

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Clinical intelligence—like having a peer at your side

“In the UpToDate Expert AI, it’s like I’m having conversations that suggest the next question that I should be thinking of, and I find that really helpful.”

Physician Assistant, Primary Care

Trusting the content

“If I can trust UpToDate to begin with, then getting an AI-powered summary that's coming right from UpToDate—and nowhere else—is going to allow for that increased trust. It's an exciting direction we're heading in.”

— Clinician, Internal Medicine, 5 years of practice

Augmenting clinician judgment

“I want supportive decisions as opposed to automated decisions. I'd rather have tools that support my decision-making as opposed to creating it for me and looking for a checkoff that I approve.”

— Physician Assistant, Tier 1 university health system

Transparency in generated responses

“Compared to other products, the transparency in UpToDate Expert AI is 1A. The assumptions section—where it says ‘I’m assuming this patient is not pregnant, not a child, doesn’t have major comorbidities’—puts it above all the other tools I’ve tried.”

— Medical Librarian

An established trust in UpToDate

“I trust UpToDate. And that level of trust allows me to know that if this is an UpToDate product, I know it's been rigorously tested and it's showing me what it's supposed to show me.”

— Clinician, Internal Medicine, 10 years of practice

Explore more on the future of AI in clinical decision support

  • Key Challenges

  • Whitepapers

  • Our Expertise

Frequently Asked Questions About UpToDate Expert AI

  • What clinical decision support can UpToDate Expert AI provide?
    UpToDate Expert AI is an interactive GenAI-powered clinical reasoning tool grounded in the evidence-based content from UpToDate. It helps you think through cases, clarify concepts, and answer clinical questions.
  • Who can purchase UpToDate Expert AI?
    UpToDate Expert AI is available to both UpToDate Enterprise and Professional users.
    • Hospitals and health systems: UpToDate Expert AI is available to clinicians in select health systems through their UpToDate Enterprise Edition subscription. Contact us to discuss how you and your health system can get access.
    • Individual subscribers: Visit the UpToDate webstore to subscribe to UpToDate Pro Plus or trainee package with Expert AI. 
  • Is UpToDate Expert AI available on a mobile device?
    Yes, you can access it through desktop or the UpToDate mobile app. 
  • How is UpToDate Expert AI different from the standard UpToDate solution?
    This GenAI solution builds on our legacy of providing trusted clinical answers. It interprets clinical questions, explains reasoning, highlights assumptions, and provides personalized, context-aware recommendations in an intuitive chat format — mirroring a consultation with a trusted expert.  
  • What content sources does UpToDate Expert AI use to generate responses?
    Built on the trusted evidence-based content from UpToDate, UpToDate Expert AI draws exclusively from our rigorously maintained clinical information, and developed with AI standards that prioritize transparency, evidence, and clinical integrity. Every answer is traceable and includes direct links to UpToDate topics.
  • How does UpToDate ensure responsible, trusted development of AI capabilities?
    Grounded in expert-driven development, our standards ensure AI tools are designed and validated by clinical professionals, reducing errors and providing evidence-based, actionable insights.

Ready to revolutionize your care delivery with AI?

Explore personal subscriptions

UpToDate Expert AI is included in the new UpToDate Pro Plus package for individual professional subscribers as well as personal trainee subscriptions in the U.S.

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