HealthJune 28, 2024

Mastering medication value sets for improved healthcare analytics

Explore the importance of medication value sets in healthcare analytics. Learn how expert curation and advanced technologies simplify data management, improve patient outcomes, and enhance decision-making. 

In the continuously evolving landscape of healthcare analytics and interoperability, increasingly intricate data surrounding medications is driving pivotal decisions that have sweeping implications across the care continuum. Understanding the complexities of representing medication data in standardized value sets —how they originate and the role they play in the grand scheme of healthcare data—is essential for clinical informaticists, researchers, and those striving for operational efficiency and improving the precision of patient care. This exploration outlines the nuanced challenges within the medication data domain, why they matter, and how innovative approaches can alleviate the burden of creating and maintaining value sets, yielding streamlined, beneficial solutions.

The pivotal role of medication data in healthcare decision-making

There is a lot of medication data in today's world. The CDC estimated between the years of 2015-2018 that 48.6% of adults in the United States have used a prescription medication in the last 30 days. Although medication-related data may be marked as a central pillar of the healthcare data ecosystem, data disparity remains a major obstacle for informaticists, data analysts, and clinical researchers. The integrity and organization of this data supply are non-negotiable, considering the domino effect it generates across various healthcare landscapes as it informs critical decisions related to treatment plans, patient outcomes, and a myriad of functions vital to the delivery of care.

Medication value sets are complex groupings of data elements representing medications, often organized based on therapeutic use or other commonalities. Developing and curating these sets is crucial as they significantly impact the quality of data-driven decisions. For instance, research by Kiser, Eibeck, and Ferraro demonstrated that using standardized vocabularies to aggregate features from disparate electronic health records (EHR) data improved the transferability of a machine learning model designed to detect postoperative healthcare-associated infections. Their sensitivity analysis revealed that value sets from medications and diagnosis codes were more critical to model transferability than other clinical domains like laboratory tests. This study shows that standardizing disparate data into semantically equivalent groups is an effective way to address data dissimilarities across multiple sources. 

Navigating through the complexity of medication data

Developing a medication value set isn't as straightforward as compiling a list of drugs. It involves meticulous creation, validation, and maintenance processes to ensure that the data is not only correct but also remains current in the face of a dynamic healthcare environment awash with new pharmaceuticals, altered indications, and evolving terminologies. Source data that represent medication use will come in different forms depending on the healthcare setting. For example, National Drug Codes (NDC) are used for prescription drug insurance claims but can also be found in EHR data, along with RxNorm codes and proprietary drug data base concepts like Medi-Span Generic Product Identifiers (GPI)

The disparate codified standards for medications necessitate aggregation into a single semantic group for effective analytics. The same medication terminologies that source data often comes in can serve as the canvas on which these value sets are painted, enabling interoperability and uniformity across platforms. Yet, in execution, the task is complex. For instance, establishing a value set for ACE inhibitors entails more than just listing the drugs deemed within this class; it necessitates a robust methodology to define, translate, and ensure the longevity of this set across the spectrum of medication terminologies.

Challenges in maintaining medication data

Medication terminologies are constantly changing, with updates and additions necessitating revisions to established value sets. Without the appropriate tools, this perpetual maintenance creates a financial, temporal, and intellectual resource vacuum, which, when managed poorly, invites errors that can cascade into compromised decision-making.

What seems like a simple example of a medication value set can quickly become overwhelming. Take for example ACE inhibitors, a common class of medications used to treat high blood pressure and other cardiovascular diseases. There are 11 medications or ingredient concepts in this class (e.g., lisinopril, captopril, benazepril), excluding combination drugs (e.g. benaepril + hydrochlorothiazide). These 11 ingredients translate into nearly 82 dispensable concepts, approximately 2,800 current NDC codes, and almost 7,300 retired NDC codes, depending on the look-back period. This relatively simple clinical example illustrates the myriad of permutations that demand continuous attention. To respond systematically, the approach to medication value set maintenance requires a cyclical process that balances innovation with efficiency.

How technology can simplify value set management for enhanced insights

The collaboration between Health Language and Medi-Span is a great example of how cooperating technologies can enhance the development and maintenance of medication value sets. This alliance amplifies the precision in medication value set authoring and maintenance by leveraging the therapeutic class hierarchy provided by Medi-Span's GPI system, while the algorithmic prowess of the Health Language platform streamlines cross-vocabulary applicability. This combination allows for improved accuracy and efficiency when authoring and ability to maintain accurate medication value sets 

These technological advancements are not just about managing complexity; they propel the industry forward with enhanced insights and operational agility. By integrating the ability to use both internal and external vocabulary relationships, deploying sophisticated clinical logic, and employing powerful analytics, we use the perfect solution for precise curation of value sets that will result in maximum impact of and insight from medication data.

A continual cycle of improvement

The trajectory of healthcare is irrevocably linked to the trajectory of the data that fuels its engines. For medication data, the challenges are significant, but the evolution is promising. With a renewed focus on precision in medication data management and the simplified workflows provided by collaborative technologies, the potential for improving patient outcomes and healthcare operational efficiency is brighter than ever.

Looking forward, the industry must band together—leveraging not only the latest in technology but also the collective wisdom of clinical informaticists—to craft a sustainable future where medication value sets not only keep pace with innovation but actively drive it forward. This is more than a theoretical exercise; it is an act of resilience, adaptability, and foresight—a testament to the industry's dedication to the very core of its existence: the wellbeing of its patients.

In conclusion, the delicacy and detail of managing medication data are monstrous tasks; they demand not just accuracy but foresight, innovation, and a shared commitment. Healthcare is a collective endeavor, and in handling the intricacy and sensitivity of medication data, our shared pursuit must be relentless in its commitment to excellence. We're here to support you in your data journey - speak to an expert today to learn more about managing medication value sets. 

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Medical Informatics Specialist, Health Language
As a Medical Informatics Specialist, Derek Pinnell, PharmD, supports Health Language solutions, focusing on medication data, providing clinical input for content and solution development, and finding innovative strategies to help clients make better use of their clinical data. 
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