New Off-Label Uses
Monograph | Off-Label Use Proposed | Date | Participating Panel Member(s) | Strength of Recommendation | Level of Evidence | Off-Label Use Vote Record | Panel Member Conflict of Interest Statement |
---|---|---|---|---|---|---|---|
Goserelin | Breast cancer, early stage, premenopausal ovarian preservation during chemotherapy | 2015.03 (updated 2022.04) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B | For the Off-Label Use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cisplatin | Breast cancer (triple-negative) | 2015.04 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP |
Equivocal | B | For the Off-Label Use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cisplatin | Penile cancer | 2015.04 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Nick Link, PharmD, BCOP Mark Holdsworth, PharmD |
Equivocal | B | For the Off-Label Use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Idarubicin | AML (Pediatric), newly diagnosed | 2015.04 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Mark Holdsworth, PharmD Heidi Trinkman, PharmD Polly Kintzel, PharmD, BCOP, BCPS |
Strong (for off-label use) | A | For the Off-Label Use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Idarubicin | AML (Pediatric), relapsed/refractory | 2015.04 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Mark Holdsworth, PharmD Heidi Trinkman, PharmD Polly Kintzel, PharmD, BCOP, BCPS |
Equivocal | B | For the Off-Label Use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Topotecan | Primary CNS lymphoma, relapsed/refractory | 2015.06 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Corey Carter, MD Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | C | For the Off-Label Use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Nivolumab | Melanoma, unresectable or metastatic (without BRAF mutation), first-line, single-agent therapy | 2015.07 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Palbociclib | Breast cancer, advanced (second-line endocrine-based therapy) | 2015.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Omer Koc, MD Nick Link. PharmD, BCOP |
Strong | A | For the Off-Label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Fulvestrant | Breast cancer, advanced (second-line endocrine-based combination therapy) | 2015.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Omer Koc, MD Nick Link. PharmD, BCOP |
Strong | A | For the Off-Label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cabozantinib | Renal cell cancer, clear cell (advanced) | 2015.11 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Strong | A | For the Off-Label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Nivolumab | Renal cell cancer, clear cell (advanced) | 2015.11 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Strong | A | For the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest Conflict of Interest No Conflict of Interest No Conflict of Interest |
Goserelin | Breast cancer, advanced with endocrine-based combination therapy | 2015.11 (updated 2022.04) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Nick Link. PharmD, BCOP |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Ipilimumab | Melanoma, unresectable or metastatic, first-line combination therapy | 2015.11 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link. PharmD, BCOP |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Trabectedin | Ovarian cancer, refractory (platinum-sensitive) | 2016.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Docetaxel | Prostate cancer, metastatic, hormone-sensitive | 2016.03 (updated 2024.03) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP |
Strong | A, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Vemurafenib | Erdheim-Chester disease, refractory (with BRAF V600E mutation) | 2016.05 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Vemurafenib | Non-small cell lung cancer, refractory (with BRAF V600 mutation) | 2016.05 (updated 2022.02) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Angela German, PharmD, BCOP |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Nivolumab | Head and neck cancer, squamous cell (recurrent or metastatic) | 2016.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Axitinib | Thyroid cancer (advanced, differentiated) | 2016.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Mark Holdsworth, PharmD Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Carfilzomib | Waldenström macroglobulinemia | 2016.07 (updated 2022.07) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Regorafenib | Hepatocellular cancer (intermediate or advanced) | 2016.07 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Mark Holdsworth, PharmD Omer Koc, MD |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Pembrolizumab | Merkel cell carcinoma (advanced) | 2016.08 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Dabrafenib | Non-small cell lung cancer, metastatic, relapsed or refractory (with BRAF V660E mutation) | 2016.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Trametinib | Non-small cell lung cancer, metastatic, relapsed or refractory (with BRAF V660E mutation) | 2016.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Nivolumab | Small cell lung cancer (progressive) | 2016.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Mitomycin | Vulvar cancer, advanced | 2016.11 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Corey Carter, MD Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Carboplatin | Anal cancer | 2016.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Corey Carter, MD Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | C | For the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Carboplatin | Gastric cancer | 2016.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Corey Carter, MD Omer Koc, MD Nick Link, PharmD, BCOP |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Carboplatin | Thyroid Cancer | 2016.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Corey Carter, MD Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Carboplatin | Wilms Tumor | 2016.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Mark Holdsworth, PharmD Heidi Trinkman, PharmD |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Fluorouracil | Vulvar cancer, advanced | 2016.12 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Bevacizumab | Malignant pleural mesothelioma (unresectable) | 2016.12 (updated 2020.11) |
Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Omer Koc, MD Nick Link, PharmD, BCOP |
Strong | A, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Bevacizumab | Hereditary hemorrhagic telangiectasia | 2016.12 (updated 2020.04) |
Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Nick Link, PharmD, BCOP Heidi Trinkman, PharmD |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Temsirolimus | Endometrial cancer (locally advanced, recurrent and/or metastatic) | 2017.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Pembrolizumab | Urothelial carcinoma (advanced) | 2017.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Sargramostim | Neuroblastoma, high-risk (pediatrics) | 2017.03 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Polly Kintzel, PharmD, BCOP, BCPS Heidi Trinkman, PharmD |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Isotretinoin | Neuroblastoma, high-risk (pediatrics) | 2017.04 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Polly KIntzel, PharmD, BCOP, BCPS Heidi Trinkman, PharmD |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Ipilimumab | Small cell lung cancer (progressive) | 2017.04 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Tocilizumab | Cytokine release syndrome (due to BiTE therapy), severe or life-threatening | 2017.04 (modified 2017.09) | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Polly Kintzel, PharmD, BCOP, BCPS Heidi Trinkman, PharmD Omer Koc, MD |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Capecitabine | Pancreatic cancer (adjuvant therapy) | 2017.04 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Gemcitabine | Pancreatic cancer (adjuvant therapy) | 2017.04 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Capecitabine | Anal carcinoma | 2017.04 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Antithymocyte globulin (rabbit;Thymoglobulin) | Chronic graft-versus-host disease (prevention) | 2017.05 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Strong | A, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Olaparib | Breast cancer, metastatic, HER2-negative, BRCA-mutated | 2017.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Abiraterone | Prostate cancer, metastatic or high-risk locally advanced, castration-sensitive | 2017.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Omer Koc, MD Nick Link, PharmD, BCOP |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Rituximab | Myasthenia gravis (refractory) | 2017.07 (updated 2021.10) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP Heidi Trinkman, PharmD |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Rituximab | Neuromyelitis optica (relapse prevention) | 2017.07 (updated 2021.10) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Rituximab | Pemphigus vulgaris (newly diagnosed) | 2017.07 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP Heidi Trinkman, PharmD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Capecitabine | Breast cancer (adjuvant therapy) | 2017.07 (updated 2019.03) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Omer Koc, MD Nick Link, PharmD, BCOP |
Strong | A, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Capecitabine | Hepatobiliary cancer (adjuvant therapy) | 2017.07 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Bevacizumab | Gliomas (recurrent or progressive (pediatrics) | 2017.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Omer Koc, MD Heidi Trinkman, PharmD |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Bevacizumab | Medulloblastoma (relapsed or refractory) | 2017.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Nick Link, PharmD, BCOP Heidi Trinkman, PharmD |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Bevacizumab | Solid tumors, refractory (pediatrics) | 2017.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Corey Carter, MD Heidi Trinkman, PharmD |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Lenvatinib | Hepatocellular carcinoma (advanced) | 2017.11 (updated; see 2018.03) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Durvalumab | Non-small cell lung cancer (unresectable, locally advanced) | 2017.11 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Fluorouracil | Glaucoma surgery (adjunctive therapy) | 2017.11 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Alemtuzumab | Aplastic anemia, refractory | 2017.11 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Mark Holdsworth, PharmD Heidi Trinkman, PharmD |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Alemtuzumab | Hemophagocytic lymphohistiocytosis, refractory | 2017.11 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Mark Holdsworth, PharmD Heidi Trinkman, PharmD |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Irinotecan (conventional) | Small cell lung cancer (limited stage) | 2017.11 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Omer Koc, MD Corey Carter, MD Nick Link, PharmD, BCOP |
Equivocal | B, G | For the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Bevacizumab | Diabetic macular edema | 2017.11 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Mark Holdsworth, PharmD Polly Kintzel, PharmD, BCOP, BCPS |
Strong | A, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Irinotecan (conventional) | Unknown primary adenocarcinoma | 2017.12 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Omer Koc, MD Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Tamoxifen | Mastalgia, severe | 2017.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Oxaliplatin | Neuroblastoma, high-risk, relapsed/refractory (pediatrics) | 2017.12 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Nick Link, PharmD, BCOP Heidi Trinkman, PharmD |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cladribine | T-cell large granular lymphocytic leukemia (refractory) | 2017.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Alemtuzumab | Mycosis fungoides/Sezary syndrome (advanced) | 2018.01 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Jordan Lundberg, PharmD, BCOP Nick Link, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Alemtuzumab | T-cell large granular lymphocytic leukemia | 2018.01 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Jordan Lundberg, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Nilotinib | Acute lymphoblastic leukemia, Ph+ | 2018.01 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Heidi Trinkman, PharmD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Streptozocin | Gastrointestinal neuroendocrine tumors | 2018.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Trastuzumab | Breast cancer, metastatic, HER2-positive, hormone receptor-positive (in combination with an aromatase inhibitor) | 2018.03 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP |
Strong | A, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Lenvatinib | Hepatocellular carcinoma (advanced) | 2018.03 (updated from 2017.11) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Strong | A | For the updated LOE /Strength of Recommendation: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Ruxolitinib | Graft versus host disease (acute or chronic; treatment) | 2018.04 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Heidi Trinkman, PharmD |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Filgrastim | Alcoholic hepatitis (severe) | 2018.05 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Prednisone | Multiple myeloma (previously untreated; transplant ineligible) | 2018.06 (updated 2021.10) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Strong | A, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Everolimus | Hodgkin lymphoma (relapsed or refractory) | 2018.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Omer Koc, MD Nick Link, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Everolimus | Thymoma and thymic carcinomas (advanced, refractory) | 2018.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cetuximab | Penile cancer (squamous cell, advanced or metastatic) | 2018.07 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | C | For the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Methylprednisolone | Prostate cancer (metastatic, castration-resistant) | 2018.07 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Dolasetron | Chemotherapy-associated nausea and vomiting (high emetic potential) (adults) | 2018.08 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP |
Strong | G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Dolasetron | Chemotherapy-associated nausea and vomiting (low emetic potential) (adults) | 2018.08 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP |
Strong | G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Ondansetron | Carcinoid syndrome-associated diarrhea (severe, refractory; alternative agent) | 2018.08 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Nivolumab | Melanoma, metastatic with brain metastases | 2018.09 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Jordan Lundberg, PharmD, BCOP Elizabeth Connor, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Ipilimumab | Melanoma, metastatic with brain metastases | 2018.09 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Jordan Lundberg, PharmD, BCOP Elizabeth Connor, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Paclitaxel (protein bound) | Bladder cancer, metastatic, platinum-resistant | 2018.09 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Omer Koc, MD Nick Link, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Paclitaxel (protein bound) | Cervical cancer, advanced, recurrent or persistent | 2018.09 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Atezolizumab | SCLC (extensive stage; first-line therapy) | 2018.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Brigatinib | Non-small cell lung cancer, advanced, (initial ALK-inhibitor therapy) | 2018.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Ramucirumab | Hepatocellular carcinoma (advanced, relapsed/refractory) | 2018.11 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Strong | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Pembrolizumab | Melanoma, stage III (adjuvant treatment) | 2018.11 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Procarbazine | CNS tumors, low grade gliomas (in children) | 2018.11 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Heidi Trinkman, PharmD Jennifer Thackray, PharmD, BCPPS, BCPS Mark Holdsworth, PharmD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Vincristine | Hepatoblastoma | 2018.11 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Heidi Trinkman, PharmD Jennifer Thackray, PharmD, BCPPS, BCPS Mark Holdsworth, PharmD |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Doxorubicin (conventional) | Hepatoblastoma (pediatrics) | 2018.12 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Jennifer Thackray, PharmD, BCPPS, BCPS Heidi Trinkman, PharmD Mark Holdsworth, PharmD |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cabozantinib | Hepatocellular carcinoma (advanced) | 2018.12 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Carfilzomib | Multiple myeloma (newly diagnosed) | 2019.01 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Trastuzumab | Endometrial cancer (uterine serous), advanced or recurrent, HER2-positive | 2019.01 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Ado-trastuzumab emtansine | Breast cancer, early, HER2-positive (adjuvant therapy for residual disease) | 2019.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Zoledronic acid | Breast cancer, early stage, adjuvant therapy in postmenopausal females | 2019.04 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B,G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Oxaliplatin | Pancreatic cancer, potentially curable (adjuvant therapy) | 2019.05 (updated 2019.07) |
Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Strong | A, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Leucovorin calcium | Pancreatic cancer, potentially curable (adjuvant therapy) | 2019.05 (updated 2019.07) |
Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Strong | A, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Irinotecan | Pancreatic cancer, potentially curable (adjuvant therapy) | 2019.05 (updated 2019.07) |
Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Strong | A, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Ibandronate | Prostate cancer, metastatic, bone pain (alternative agent) | 2019.05 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Nick Link, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Vincristine | Merkel cell carcinoma | 2019.05 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Venetoclax | Mantle cell lymphoma, relapsed/refractory | 2019.06 (updated 2023.07) |
Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Capecitabine | Head and neck cancer, squamous cell (recurrent or metastatic; palliative treatment) | 2019.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP Nick Link, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Mitomycin | Hepatocellular carcinoma (chemoembolization) | 2019.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Nick Link, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Olaparib | Pancreatic cancer, metastatic, BRCA-mutated (maintenance therapy) | 2019.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Vinblastine | Kaposi sarcoma, oral lesions (intralesional) | 2019.07 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Mark Holdsworth, PharmD Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Encorafenib | Colorectal cancer, metastatic, refractory (RAS wild-type, BRAF V600E-mutant) | 2019.07 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Binimetinib | Colorectal cancer, metastatic, refractory (RAS wild-type, BRAF V600E-mutant) | 2019.07 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cetuximab | Colorectal cancer, metastatic, refractory (RAS wild-type, BRAF V600E-mutant) | 2019.07 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Ziv-aflibercept | Ascites (malignant; due to malignant ovarian cancer) | 2019.08 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP Elizabeth Connor, MD |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Chlorambucil | Necrobiotic xanthogranuloma | 2019.08 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Omer Koc, MD Nick Link, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Chlorambucil | Idiopathic membranous nephropathy | 2019.08 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Mark Holdsworth, PharmD |
Equivocal | B,G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Pentostatin | T-cell large granular lymphocytic leukemia | 2019.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Mesna | Prevention of cyclophosphamide-induced hemorrhagic cystitis in patients with rheumatic or autoimmune disorders | 2019.11 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP |
Equivocal | C | For the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Etoposide | Hemophagocytic lymphohistiocytosis | 2019.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Jordan Lundberg, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Pazopanib | Desmoid tumors (progressive) | 2019.12 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Luspatercept | Anemia due to lower-risk myelodysplastic syndromes with ring sideroblasts | 2020.01 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Polly Kintzel, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Lenalidomide | Smoldering multiple myeloma (high-risk) | 2020.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Regorafenib | Osteosarcoma, metastatic, progressive (recurrent, relapsed, or refractory) | 2020.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Jennifer Thackray, PharmD, BCPPS, BCPS |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Pembrolizumab | Breast cancer (triple negative, early stage) | 2020.03 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP Elizabeth Connor, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Pembrolizumab | Mycosis fungoides, Sézary syndrome (relapsed or refractory) | 2020.03 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP Nick Link, PharmD, BCOP Angela German, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Interferon alfa-2b | Essential thrombocythemia (advanced) | 2020.05 (updated 2022.01) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Interferon alfa-2b | Myelofibrosis (early) | 2020.05 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Mark Holdsworth, PharmD Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Interferon alfa-2b | Polycythemia vera (advanced) | 2020.05 (updated 2022.01) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Daratumumab | Systemic light chain amyloidosis (relapsed) | 2020.05 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Pembrolizumab | Malignant pleural mesothelioma, relapsed or refractory, with PD-L1 expression | 2020.05 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP Omer Koc, MD |
Equivocal | C | For the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Porfimer | Cholangiocarcinoma (unresectable) | 2020.06 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Fam-trastuzumab deruxtecan | Gastric cancer, advanced, previously treated (HER2-positive) | 2020.07 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Paclitaxel (conventional) | Anal cancer (advanced) | 2020.08 |
Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Avelumab | Gestational trophoblastic neoplasia, resistant | 2020.09 |
Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Doxorubicin (liposomal) | Castleman disease, multicentric (human herpes virus-8-associated) | 2020.10 |
Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Doxorubicin (liposomal) | Diffuse large B-cell lymphoma | 2020.10 |
Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Paclitaxel (protein bound) | Biliary tract cancer (advanced) | 2020.10 |
Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Fluorouracil (topical) | Penile carcinoma (in situ) | 2020.10 |
Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Nick Link, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Fluorouracil (topical) | Squamous cell carcinoma (in situ; Bowen disease) | 2020.10 |
Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Nick Link, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Osimertinib | Non-small cell lung cancer (adenocarcinoma), with leptomeningeal metastases (EGFR mutation-positive) | 2020.12 (updated 2024.03) |
Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cyclophosphamide | Castleman disease, idiopathic, multicentric | 2020.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Elizabeth Connor, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cyclophosphamide | Graft-versus-host disease (acute and chronic), prophylaxis | 2020.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Polly Kintzel, PharmD, BCOP, BCPS Elizabeth Connor, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cyclophosphamide | Merkel cell carcinoma | 2020.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cyclophosphamide | Osteosarcoma (relapsed/refractory) | 2020.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Mark Holdsworth, PharmD Nick Link, PharmD, BCOP Elizabeth Connor, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cyclophosphamide | Primary CNS lymphoma | 2020.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Angela German, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cyclophosphamide | Systemic light chain amyloidosis | 2020.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Polly Kintzel, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Omer Koc, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cyclophosphamide | Thymomas (advanced or metastatic) | 2020.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP Omer Koc, MD Elizabeth Connor, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Methotrexate | Large granular lymphocyte leukemia (symptomatic) | 2021.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Jordan Lundberg, PharmD, BCOP Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Methotrexate | Primary cutaneous anaplastic large cell lymphoma | 2021.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Eribulin | Uterine leiomyosarcoma, refractory | 2021.03 |
Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Elizabeth Connor, MD Omer Koc, MD Polly Kintzel, PharmD, BCOP, BCPS |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Carboplatin | Prostate cancer, castration-resistant, metastatic | 2021.03 |
Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Elizabeth Connor, MD Mark Holdsworth, PharmD Craig Vargo, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Docetaxel | Thyroid carcinoma, anaplastic | 2021.03 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Mark Holdsworth, PharmD Jordan Lundberg, PharmD, BCOP |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Docetaxel | Bladder cancer, non-muscle invasive, refractory (intravesical) | 2021.03 |
Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP Craig Vargo, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Docetaxel | Uterine sarcoma (advanced or high-grade) | 2021.03 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Carboplatin | Gestational trophoblastic neoplasia, high-risk, refractory | 2021.04 (updated 2022.02) |
Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Elizabeth Connor, MD Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Docetaxel | Anal carcinoma (squamous cell), advanced | 2021.04 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Omer Koc, MD Craig Vargo, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Melphalan | Regional perfusion in solid tumors (melanoma and soft tissue sarcoma) | 2021.04 |
Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Elizabeth Connor, MD Mark Holdsworth, PharmD Craig Vargo, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Melphalan | Hematopoietic stem cell transplant (allogeneic), reduced intensity conditioning regimen (hematologic malignancies) | 2021.04 |
Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Erlotinib | Renal cell carcinoma, papillary (advanced) | 2021.05 |
Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Elizabeth Connor, MD Mark Holdsworth, PharmD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Zanubrutinib | Waldenström macroglobulinemia | 2021.06 |
Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Ofatumumab | Waldenström macroglobulinemia, relapsed or refractory | 2021.06 |
Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Klodiana Neme, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Fam-trastuzumab deruxtecan | Colorectal cancer, metastatic, HER2-expressing | 2021.07 |
Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Craig Vargo, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Triptorelin | Breast cancer, premenopausal ovarian suppression during adjuvant endocrine therapy | 2021.07 |
Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP Craig Vargo, PharmD, BCOP |
Strong | A, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Triptorelin | Breast cancer, premenopausal ovarian preservation during chemotherapy | 2021.07 |
Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP Craig Vargo, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Acalabrutinib | Waldenström macroglobulinemia | 2021.07 |
Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Elizabeth Connor, MD Jordan Lundberg, PharmD, BCOP Klodiana Neme, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cyclophosphamide | Lymphodepleting therapy prior to chimeric antigen receptor (CAR) T-cell immunotherapy | 2021.08 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Fludarabine | Lymphodepleting therapy prior to chimeric antigen receptor (CAR) T-cell immunotherapy | 2021.08 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Olaparib | Breast cancer, early, high risk, HER2-negative, germline BRCA-mutated, adjuvant therapy | 2021.08 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Omer Koc, MD Craig Vargo, PharmD, BCOP |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Romidepsin | Peripheral T-cell lymphoma, relapsed/refractory | 2021.09 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Venetoclax | Multiple myeloma, relapsed/refractory, t(11;14) | 2021.09 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Elizabeth Connor, MD Omer Koc, MD Klodiana Neme, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Oxaliplatin | Small bowel adenocarcinoma (advanced or metastatic) | 2021.09 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Matthew Arango, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Fam-trastuzumab deruxtecan | Non-small cell lung cancer, metastatic, relapsed/refractory, nonsquamous, HER2-mutant | 2021.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Nick Link, PharmD, BCOP Craig Vargo, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Ifosfamide | Extra nodal NK/T-cell lymphoma, nasal type | 2021.12 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Omer Koc, MD Jordan Lundberg, PharmD, BCOP Klodiana Neme, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Ifosfamide | Gestational trophoblastic neoplasia, high-risk, refractory | 2021.12 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Mark Holdsworth, PharmD Polly Kintzel, PharmD, BCOP, BCPS |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Ifosfamide | Penile cancer, metastatic, squamous cell | 2021.12 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Mark Holdsworth, PharmD Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Ifosfamide | Uterine carcinosarcoma | 2021.12 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Exemestane | Breast cancer, high-risk, hormone receptor-positive, adjuvant endocrine therapy (in combination with ovarian function suppression) in premenopausal patients | 2021.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Craig Vargo, PharmD, BCOP Elizabeth Connor, MD Mark Holdsworth, PharmD |
Strong | A, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Rucaparib | Pancreatic cancer, locally advanced or metastatic, germline BRCA2-mutated, maintenance therapy | 2021.12 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Matthew Arango, PharmD, BCOP Elizabeth Connor, MD Klodiana Neme, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Peginterferon alfa-2a | Essential thrombocythemia, advanced | 2022.01 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Jordan Lundberg, PharmD, BCOP Nick Link, PharmD, BCOP |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Peginterferon alfa-2a | Polycythemia vera, advanced | 2022.01 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Jordan Lundberg, PharmD, BCOP Nick Link, PharmD, BCOP |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Epirubicin | Bladder cancer, non-muscle invasive | 2022.01 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Nick Link, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Bleomycin | Gestational trophoblastic neoplasia, high-risk, refractory | 2022.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Mark Holdsworth, PharmD Polly Kintzel, PharmD, BCOP, BCPS |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Paclitaxel (conventional) | Gestational trophoblastic neoplasia, high-risk, refractory | 2022.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Mark Holdsworth, PharmD Polly Kintzel, PharmD, BCOP, BCPS |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Polatuzumab vedotin | Diffuse large B-cell lymphoma, intermediate or high-risk, previously untreated | 2022.02 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP Klodiana Neme, PharmD, BCOP Omer Koc, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Filgrastim | Fanconi anemia (neutropenia) | 2022.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP |
Equivocal | G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Trametinib | Ovarian carcinoma, serous, low-grade, recurrent | 2022.03 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Angela German, PharmD, BCOP Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Doxorubicin (conventional) | Adult T-cell leukemia/lymphoma | 2022.03 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Klodiana Neme, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Doxorubicin (conventional) | Neuroendocrine tumors, pancreatic | 2022.03 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Matthew Arango, PharmD, BCOP Elizabeth Connor, MD Mark Holdsworth, PharmD |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Doxorubicin (conventional) | Adrenocorticol carcinoma, advanced | 2022.03 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Elizabeth Connor, MD Mark Holdsworth, PharmD |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cyclosporine (systemic) | Aplastic anemia | 2022.03 (updated 2022.11) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Strong | A, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cyclosporine (systemic) | T-cell large granular lymphocytic leukemia, symptomatic | 2022.03 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Goserelin | Breast cancer, premenopausal ovarian suppression during adjuvant endocrine therapy | 2022.04 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Omer Koc, MD Craig Vargo, PharmD, BCOP |
Strong | G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cemiplimab | Cervical carcinoma, recurrent or metastatic | 2022.05 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Rituximab | Acute lymphoblastic leukemia, B-cell precursor, CD20-positive | 2022.05 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Klodiana Neme, PharmD, BCOP Mark Holdsworth, PharmD |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Enasidenib | Acute myeloid leukemia, newly diagnosed | 2022.05 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP Angela German, PharmD, BCOP Omer Koc, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Enasidenib | Myelodysplastic syndromes, high-risk, relapsed/refractory | 2022.05 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP Angela German, PharmD, BCOP Omer Koc, MD |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Filgrastim | Hematopoietic cell mobilization in healthy donors for peripheral blood stem cells for allogeneic transplantation | 2022.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP Jennifer Thackray, PharmD, BCPPS, BCPS |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Durvalumab | Biliary tract cancer, advanced | 2022.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Matthew Arango, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Lapatinib | Colon cancer, metastatic, HER2 overexpressing, with progression on conventional chemotherapy | 2022.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Matthew Arango, PharmD, BCOP Angela German, PharmD, BCOP Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Trastuzumab | Colon cancer, metastatic, HER2 overexpressing, with progression on conventional chemotherapy | 2022.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Matthew Arango, PharmD, BCOP Angela German, PharmD, BCOP Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Fludarabine | T-cell large granular lymphocytic leukemia, relapsed/refractory | 2022.07 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Fluorouracil (systemic) | Small bowel adenocarcinoma, advanced or metastatic | 2022.07 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Matthew Arango, PharmD, BCOP Mark Holdsworth, PharmD Elizabeth Connor, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Idarubicin | Acute lymphoblastic leukemia, recurrent or refractory, salvage therapy | 2022.09 | Diedra Bragalone, PharmD, BCOP, BCPS Jennifer Godden, PharmD, BCOP Mark Holdsworth, PharmD Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Sacituzumab govotecan | Breast cancer, metastatic, hormone receptor-positive, HER2-negative, salvage therapy | 2022.09 | Diedra Bragalone, PharmD, BCOP, BCPS Jennifer Godden, PharmD, BCOP Elizabeth Conner, MD Angela German, PharmD, BCOP Craig Vargo, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Busulfan | Myeloablative conditioning prior to betibeglogene autotemcel in beta thalassemia | 2022.09 | Diedra Bragalone, PharmD, BCOP, BCPS Jennifer Godden, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP Jennifer Thackray, PharmD, BCPPS, BCPS |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Plerixafor | Hematopoietic cell mobilization prior to betibeglogene autotemcel in beta thalassemia | 2022.09 | Diedra Bragalone, PharmD, BCOP, BCPS Jennifer Godden, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP Jennifer Thackray, PharmD, BCPPS, BCPS |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Filgrastim | Hematopoietic cell mobilization prior to betibeglogene autotemcel in beta thalassemia | 2022.09 | Diedra Bragalone, PharmD, BCOP, BCPS Jennifer Godden, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP Jennifer Thackray, PharmD, BCPPS, BCPS |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Irinotecan (liposomal) | Biliary tract cancer, metastatic, progressive | 2022.09 | Diedra Bragalone, PharmD, BCOP, BCPS Jennifer Godden, PharmD, BCOP Matt Arango, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Nivolumab | Renal cell carcinoma, advanced, first-line single-agent therapy | 2022.10 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Elizabeth Connor, MD Matt Arango, PharmD, BCOP Mark Holdsworth, PharmD |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Pembrolizumab | Renal cell carcinoma, advanced, first-line single-agent therapy | 2022.10 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Elizabeth Connor, MD Matt Arango, PharmD, BCOP Mark Holdsworth, PharmD |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Rituximab | Toxicities associated with immune checkpoint inhibitor therapy, treatment | 2022.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Matt Arango, PharmD, BCOP Mark Holdsworth, PharmD Lauren Ice, PharmD, BCPS, BCOP |
Equivocal | G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Letrozole | Breast cancer, high-risk, hormone-receptor positive, adjuvant endocrine therapy in premenopausal patients (in combination with ovarian function suppression) | 2022.11 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Craig Vargo, PharmD, BCOP |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Panitumumab | Cutaneous squamous cell carcinoma, unresectable | 2022.11 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Elizabeth Connor, MD Mark Holdsworth, PharmD Omer Koc, MD |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cyclophosphamide | Pneumonitis, immune checkpoint inhibitor-induced, grade 3 or 4, steroid-refractory | 2022.11 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Matt Arango, PharmD, BCOP Mark Holdsworth, PharmD Lauren Ice, PharmD, BCPS, BCOP |
Equivocal | C, G | For the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Anastrozole | Breast cancer, high-risk, hormone receptor-positive, adjuvant endocrine therapy in premenopausal patients (in combination with ovarian function suppression) | 2022.12 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Craig Vargo, PharmD, BCOP |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Irinotecan (conventional) | Small bowel adenocarcinoma, advanced unresectable or metastatic | 2022.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Matthew Arango, PharmD, BCOP Mark Holdsworth, PharmD Elizabeth Connor, MD |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Zanubrutinib | Chronic lymphocytic leukemia, relapsed or refractory | 2023.01 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Omer Koc, MD Nick Link, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Strong | A | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Vemurafenib | Hairy cell leukemia, relapsed or refractory | 2023.02 | Stephanie Minich, PharmD, BCOP, BCPS Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Elizabeth Connor, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Ipilimumab | Merkel cell carcinoma, unresectable, recurrent, or stage IV | 2023.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Lauren Ice, PharmD, BCPS, BCOP Polly Kintzel, PharmD, BCOP, BCPS |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Nivolumab | Merkel cell carcinoma, unresectable, recurrent, or stage IV | 2023.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Lauren Ice, PharmD, BCPS, BCOP Polly Kintzel, PharmD, BCOP, BCPS |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Capecitabine | Head and neck cancer: nasopharyngeal cancer, locally advanced | 2023.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Matthew Arango, PharmD, BCOP Klodiana Neme, PharmD, BCOP Craig Vargo, PharmD, BCOP |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Capecitabine | Neuroendocrine tumors: GI/carcinoid, refractory | 2023.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Matthew Arango, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Craig Vargo, PharmD, BCOP |
Equivocal | C | For the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Capecitabine | Small bowel adenocarcinoma, advanced unresectable or metastatic | 2023.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Matthew Arango, PharmD, BCOP Omer Koc, MD Craig Vargo, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Capecitabine | Thymic malignancies, refractory | 2023.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Matthew Arango, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Craig Vargo, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Vemurafenib | Langerhans cell histiocytosis, with BRAF V600 mutation | 2023.02 | Stephanie Minich, PharmD, BCOP, BCPS Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Elizabeth Connor, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Vemurafenib | Thyroid cancer, papillary, recurrent or metastatic, BRAF V600E-mutated | 2023.02 | Stephanie Minich, PharmD, BCOP, BCPS Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Elizabeth Connor, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Capecitabine | Gastric cancer, adjuvant treatment | 2023.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Matthew Arango, PharmD, BCOP Angela German, PharmD, BCOP Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Rituximab | Hairy cell leukemia | 2023.03 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Lauren Ice, PharmD, BCPS, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Pembrolizumab | Melanoma, advanced, high-risk, resectable, neoadjuvant regimen | 2023.04 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP, BCPS Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Imiquimod | Cutaneous squamous cell carcinoma in situ (Bowen disease), low-risk | 2023.04 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP Mark Holdsworth, PharmD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Imiquimod | Melanoma in situ, lentigo maligna type | 2023.04 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP Mark Holdsworth, PharmD |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Imiquimod | Mycosis fungoides, early stage, refractory | 2023.04 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Nick Link, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Imiquimod | Penile cancer, superficial/noninvasive disease | 2023.04 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Nick Link, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Mitoxantrone | T-cell prolymphocytic leukemia | 2023.05 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP, BCPS Lauren Ice, PharmD, BCPS, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Fludarabine | T-cell prolymphocytic leukemia | 2023.05 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Lauren Ice, PharmD, BCPS, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cyclophosphamide | T-cell prolymphocytic leukemia | 2023.05 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Lauren Ice, PharmD, BCPS, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Anastrozole | Breast cancer in male patients, hormone receptor-positive | 2023.05 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Nick Link, PharmD, BCOP Craig Vargo, PharmD, BCOP |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Exemestane | Breast cancer in male patients, hormone receptor-positive | 2023.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Lauren Ice, PharmD, BCOP Nick Link, PharmD, BCOP |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Letrozole | Breast cancer in male patients, hormone receptor-positive | 2023.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Lauren Ice, PharmD, BCOP Nick Link, PharmD, BCOP |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Fulvestrant | Breast cancer in male patients, advanced or metastatic, hormone receptor-positive, HER2-negative | 2023.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP, BCPS Polly Kintzel, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Omer Koc, MD |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Goserelin | Breast cancer in male patients, hormone receptor-positive | 2023.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP, BCPS Mark Holdsworth, PharmD Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Leuprolide | Breast cancer in male patients, hormone receptor-positive | 2023.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP, BCPS Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Triptorelin | Breast cancer in male patients, hormone receptor-positive | 2023.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP, BCPS Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Leucovorin calcium | Small bowel adenocarcinoma, advanced or metastatic | 2023.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP, BCPS Matthew Arango, PharmD, BCOP Omer Koc, MD Polly Kintzel, PharmD, BCOP, BCPS |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Obinutuzumab | Diffuse large B cell lymphoma, relapsed or refractory; glofitamab pretreatment | 2023.07 | Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Lauren Ice, PharmD, BCPS, BCOP Jordan Lundberg, PharmD, BCOP Klodiana Neme, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Pirtobrutinib | Chronic lymphocytic leukemia/small lymphocytic lymphoma, relapsed or refractory | 2023.08 | Angela German, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Lauren Ice, PharmD, BCPS, BCOP Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Binimetinib | Melanoma, unresectable or metastatic, with NRAS mutation | 2023.09 | Angela German, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP Klodiana Neme, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Hydroxyurea | Chronic myelomonocytic leukemia, advanced, proliferative | 2023.09 | Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Lauren Ice, PharmD, BCPS, BCOP Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Hydroxyurea | Differentiation syndrome, cytoreduction | 2023.09 | Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Lauren Ice, PharmD, BCPS, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Hydroxyurea | Myelofibrosis, primary, symptomatic (alternative agent) | 2023.09 | Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Lauren Ice, PharmD, BCPS, BCOP Nick Link, PharmD, BCOP Klodiana Neme, PharmD, BCOP |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Copanlisib | Marginal zone lymphoma, relapsed or refractory | 2023.09 | Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Floxuridine | Cholangiocarcinoma, intrahepatic metastases, unresectable | 2023.10 | Angela German, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Matt Arango, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Streptozocin | Thyroid carcinoma, medullary, advanced or metastatic | 2023.11 | Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Mark Holdsworth, PharmD Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Mogamulizumab | Adult T cell leukemia/lymphoma, relapsed or refractory | 2023.11 | Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Pegfilgrastim | Hematopoietic support/recovery following autologous transplantation | 2023.12 | Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Lauren Ice, PharmD, BCPS, BCOP Omer Koc, MD Klodiana Neme, PharmD, BCOP |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Bicalutamide | Prostate cancer, reduction of lower urinary tract symptoms associated with tumor flare | 2024.01 | Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Mark Holdsworth, PharmD Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Bicalutamide | Salivary gland tumors, advanced, nonadenoid cystic, androgen receptor-positive | 2024.01 | Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Matthew Arango, PharmD, BCOP Elizabeth Connor, MD Nick Link, PharmD, BCOP |
Equivocal | C, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Atezolizumab | Cervical cancer, persistent, recurrent, or metastatic | 2024.02 | Angela German, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Durvalumab | Hepatocellular carcinoma, unresectable, single-agent therapy | 2024.02 | Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Matt Arango, PharmD, BCOP Lauren Ice, PharmD, BCPS, BCOP Omer Koc, MD |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Plerixafor | Hematopoietic cell mobilization prior to lovotibeglogene autotemcel in sickle cell anemia | 2024.03 | Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP Jennifer Thackray, PharmD, BCPPS, BCPS |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Busulfan | Myeloablative conditioning prior to lovotibeglogene autotemcel in sickle cell anemia | 2024.03 | Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP Jennifer Thackray, PharmD, BCPPS, BCPS |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Thiotepa | Primary CNS lymphoma, newly diagnosed, induction therapy | 2024.03 | Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Lauren Ice, PharmD, BCPS, BCOP Jordan Lundberg, PharmD, BCOP Klodiana Neme, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Docetaxel | Cervical cancer, advanced or recurrent | 2024.04 | Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Bevacizumab | Meningioma, recurrent or refractory | 2024.04 | Angela German, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Klodiana Neme, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Leucovorin calcium | Anal carcinoma, advanced | 2024.04 | Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Matthew Arango, PharmD, BCOP Mark Holdsworth, PharmD Nick Link, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Epirubicin | Peripheral T cell lymphoma, enteropathy-associated | 2024.04 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich. PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Fostamatinib | Warm autoimmune hemolytic anemia, refractory or intolerant | 2024.05 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich. PharmD, BCOP Lauren Ice, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Bendamustine | Lymphodepleting therapy prior to chimeric antigen receptor (CAR) T-cell immunotherapy | 2024.05 | Angela German, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Mark Holdsworth, PharmD Jordan Lundberg, PharmD, BCOP Jen Thackray, PharmD, BCPPS, BCPS |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Bendamustine | Peripheral T-cell lymphoma, relapsed or refractory | 2024.05 | Angela German, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Mark Holdsworth, PharmD Nick Link, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Temozolomide | Small-cell lung cancer, relapsed/refractory | 2024.05 | Diedra Bragalone, PharmD, BCOP, BCPS Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP |
Equivocal | B, G | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Pemetrexed | Primary CNS lymphoma, relapsed or refractory | 2024.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich. PharmD, BCOP Lauren Ice, PharmD, BCOP Omer Koc, MD Jordan Lundberg, PharmD, BCOP |
Equivocal | C | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Tucatinib | Biliary tract cancer, HER2-positive, metastatic | 2024.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich. PharmD, BCOP Matthew Arango, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Trastuzumab and Hyaluronidase | Breast cancer, early, HER2-positive, neoadjuvant treatment | 2024.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich. PharmD, BCOP Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Jen Thackray, PharmD, BCPPS, BCPS |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Trastuzumab | Biliary tract cancer, HER2-positive, metastatic | 2024.07 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich. PharmD, BCOP Matthew Arango, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP |
Equivocal | B | For the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Off-Label Uses Removed From Database
Monograph | Off-Label Use Removed | Date | Participating Panel Member(s) | Strength of Recommendation | Off-Label Use Removal Vote Record | Conflict of Interest Statement |
---|---|---|---|---|---|---|
Bevacizumab | Ovarian cancer, advanced, recurrent (platinum sensitive) | 2014.11 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA-approved (no panel vote needed - removed from off-label uses due to approval by FDA) | N/A | N/A |
Alemtuzumab | Multiple sclerosis | 2014.11 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA-approved (no panel vote needed - removed from off-label uses due to approval by FDA) | N/A | N/A |
Medroxyprogesterone injection | Renal Carcinoma (labeled use, add to Use: Unsupported) | 2015.02 (updated 2024.03) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Cater, MD Omer Koc, MD Polly Kintzel, PharmD, BCOP, BCPS |
Although included in the medroxyprogesterone (400 mg/mL injection) manufacturer’s labeling as adjunctive therapy and palliative treatment of inoperable, recurrent, and metastatic renal carcinoma, there is insufficient evidence to recommend medroxyprogesterone for the management of renal carcinoma when compared to other generally accepted treatments. | Add to Use: Unsupported: 5 of 5 (add to unsupported use) | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Topotecan | Merkel cell carcinoma, advanced | 2015.06 (updated 2024.04) | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Corey Carter, MD Omer Koc, MD Nick Link, PharmD, BCOP |
Although previously used as an off-label treatment, there is insufficient evidence to recommend topotecan for the management of Merkel cell carcinoma when compared to other generally accepted treatments. | Remove the Off-Label Use: 5 of 5 (add to unsupported use) | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Pegfilgrastim | Prevention of chemotherapy-induced neutropenia in children | 2015.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed - removed from off-label uses due to pediatric dosing addition to FDA labeling). | n/a | n/a |
Nivolumab | Renal cell cancer, clear cell (advanced) | 2015.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed - removed from off-label uses due to approval by FDA). | n/a | n/a |
Nivolumab | Melanoma, unresectable or metastatic (without BRAF mutation), first-line, single-agent therapy | 2015.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed - removed from off-label uses due to approval by FDA). | n/a | n/a |
Uridine Triacetate | Fluorouracil overdose/overexposure | 2015.12 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed - removed from off-label uses due to approval by FDA). | n/a | n/a |
Palbociclib | Breast cancer, advanced (second-line endocrine-based therapy) | 2016.03 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed - removed from off-label uses due to approval by FDA). | n/a | n/a |
Fulvestrant | Breast cancer, advanced (second-line endocrine-based therapy) | 2016.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed - removed from off-label uses due to approval by FDA). | n/a | n/a |
Cabozantinib | Renal cell carcinoma, advanced | 2016.05 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Ifosfamide | Small cell lung cancer | 2016.09 (updated 2024.03) | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Corey Carter, MD Omer Koc, MD Nick Link, PharmD, BCOP |
Against off-label use: Although ifosfamide had previously been used off-label for the treatment of small cell lung cancer, available literature suggest a lack of improvement in clinical outcomes and increased toxicity with the addition of ifosfamide to standard therapy. Other contemporary therapies have replaced the use of ifosfamide for management of small cell lung cancer. | Remove the off-label use: 5 of 5 (Add to Use: Unsupported) | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Nivolumab | Head and neck cancer, squamous cell (recurrent or metastatic) | 2016.11 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed - removed from off-label uses due to approval by FDA). | n/a | n/a |
Mitomycin | Non-small cell lung cancer | 2016.11 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP |
Against off-label use: Evidence suggests a lack of support for this off-label use; other contemporary therapies have replaced the use of mitomycin for the treatment of non-small cell lung cancer. | Remove the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Fluorouracil | Thymic cancers | 2017.01 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD. BCOP |
Against off-label use: A lack of evidence suggests a lack of support for this off-label use. | Remove the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Antithymocyte globulin (rabbit;Thymoglobulin) | Myelodysplastic syndrome (low risk; non-sideroblastic) | 2017.05 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Corey Carter, MD Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD. BCOP |
Against off-label use: A lack of evidence for antithymocyte globulin (rabbit; Thymoglobulin) suggests a lack of support for this off-label use. | Remove the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Regorafenib | Hepatocellular carcinoma (intermediate or advanced) | 2017.05 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed - removed from off-label uses due to approval by FDA). | n/a | n/a |
Pembrolizumab | Urothelial carcinoma (advanced) | 2017.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed - removed from off-label uses due to approval by FDA). | n/a | n/a |
Dabrafenib | Non-small cell lung cancer, metastatic, relapsed or refractory (with BRAF V600E mutation) | 2017.07 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed - removed from off-label uses due to approval by FDA). | n/a | n/a |
Trametinib | Non-small cell lung cancer, metastatic, relapsed or refractory (with BRAF V600E mutation) | 2017.07 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed - removed from off-label uses due to approval by FDA). | n/a | n/a |
Tocilizumab | Cytokine release syndrome (due to CAR-T cell therapy) | 2017.09 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Vemurafenib | Erdheim-Chester disease, refractory (with BRAF V600E mutation) | 2017.11 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed - removed from off-label uses due to approval by FDA). | n/a | n/a |
Busulfan (oral) | Chronic myeloid leukemia (palliative treatment) | 2017.12 (updated 2024.03) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Heidi Trinkman, PharmD |
Against the use: Although palliative treatment of chromic myeloid leukemia (CML) is as an approved use in the manufacturer’s labeling for busulfan tablets, other contemporary therapies have replaced the use of oral busulfan for management of CML. According to the European LeukemiaNet Recommendations for Management of CML, recommended treatments include tyrosine kinase inhibitors, omacetaxine, or allogeneic transplant, however, oral busulfan (unless part of a transplant conditioning regimen) is not recommended (Baccarani 2013). | Remove the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cladribine | Chronic myeloid leukemia (palliative treatment) | 2017.12 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Omer Koc, MD Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP |
Against off-label use: Evidence suggests a lack of support for this off-label use; other contemporary therapies have replaced the use of cladribine for the treatment of chronic lymphocytic leukemia. | Remove the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Olaparib | Breast cancer, metastatic, HER2-negative, BRCA-mutated | 2018.01 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Abiraterone | Prostate cancer, metastatic or high-risk locally advanced, castration-sensitive | 2018.02 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Durvalumab | Non-small cell lung cancer (unresectable, locally advanced) | 2018.03 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Sargramostim | Hematopoietic radiation injury syndrome, acute | 2018.04 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Estramustine | Prostate cancer (metastatic castration-resistant) | 2018.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP |
Although estramustine is approved for palliative treatment of progressive or metastatic prostate cancer, guidelines from the American Society of Clinical Oncology/ Cancer Care Ontario (for systemic therapy in men w/metastatic castration-resistant prostate cancer) recommend against offering estramustine in patients with metastatic castration-resistant prostate cancer due to a lack of benefit in survival or quality of life and an increased risk of toxicity (ASCO [Basch 2014]). | Remove the use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Rituximab | Pemphigus vulgaris (newly diagnosed) | 2018.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved; (no panel vote needed – removed from off-label uses due to FDA approval) | n/a | n/a |
Cetuximab | NSCLC, EGFR-expressing, advanced | 2018.07 (updated 2024.03) | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Elizabeth Connor, MD Omer Koc, MD Nick Link, PharmD, BCOP |
Although cetuximab had previously been an off-label option for the treatment of stage IV non-small cell lung cancer, the 2015 update of the American Society of Clinical Oncology guidelines for Systemic Therapy for Stage IV Non-Small Cell Lung Cancer removed the recommendation to consider cetuximab as a treatment option (ASCO [Masters 2015]). | Remove the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Vinblastine | Breast cancer | 2018.07 (updated 2024.04) | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Elizabeth Connor, MD Omer Koc, MD Nick Link, PharmD, BCOP |
Although included as a use in the manufacturer’s prescribing information, other contemporary therapies have replaced the use of vinblastine for the treatment of refractory breast cancer. | Remove the use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Nivolumab | Small cell lung cancer (progressive) | 2018.08 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed – removed from off-label uses due to FDA approval) | n/a | n/a |
Lenvatinib | Hepatocellular carcinoma (advanced) | 2018.08 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to FDA approval) | n/a | n/a |
Dactinomycin | Osteosarcoma | 2018.09 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP Jennifer Thackray, PharmD, BCPPS, BCPS Mark Holdsworth, PharmD |
Limited (older) data exists for the use of chemotherapy regimens containing dactinomycin in the treatment of non-metastatic osteosarcoma; other contemporary chemotherapy regimens have replaced the use of dactinomycin-containing regimens for management of osteosarcoma. | Remove the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Mechlorethamine | Bronchogenic carcinoma (palliative treatment) | 2018.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP |
Although included in the manufacturer's labeling as a use, other contemporary therapies have replaced the use of mechlorethamine in the palliative management of bronchogenic carcinoma. | Remove the use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Mechlorethamine | Chronic lymphocytic leukemia (palliative treatment) | 2018.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Omer Koc, MD Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP |
Although included in the manufacturer's labeling as a use, other contemporary therapies have replaced the use of mechlorethamine in the palliative management of chronic lymphocytic leukemia (CLL). CLL guidelines and treatment recommendations do not include mechlorethamine as a treatment option (ESMO [Eichhorst 2015]; iwCLL [Hallek 2018]). | Remove the use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Mechlorethamine | Chronic myelocytic leukemia (palliative treatment) | 2018.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Omer Koc, MD Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP |
Although included in the manufacturer's labeling as a use, other contemporary therapies have replaced the use of mechlorethamine injection in the palliative management of chronic myelocytic (myeloid) leukemia (CML). CML guidelines and treatment recommendations do not include mechlorethamine as a treatment option (ELN [Baccarini 2013]; ESMO [Hochhaus 2017]). | Remove the use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Mechlorethamine | Lymphosarcomas (palliative treatment) | 2018.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Nick Link, PharmD, BCOP Jennifer Thackray, PharmD, BCPPS, BCPS |
Although included in the manufacturer's labeling as a use, other contemporary therapies have replaced the use of mechlorethamine injection in the palliative management of lymphosarcomas. | Remove the use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Mechlorethamine | Malignant effusion from metastatic carcinomas (palliative treatment) | 2018.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP Jennifer Thackray, PharmD, BCPPS, BCPS |
Although included in the manufacturer's labeling as a use, other contemporary therapies have replaced the use of mechlorethamine injection in the palliative management of malignant effusions. | Remove the use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Mechlorethamine | Mycosis fungoides (palliative treatment) | 2018.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Polly Kintzel, PharmD, BCOP, BCPS Heidi Trinkman, PharmD |
Although included in the manufacturer's labeling as a use, other contemporary therapies have replaced the use of IV mechlorethamine in the palliative management of mycosis fungoides. A topical mechlorethamine product is commercially available and approved for treatment of mycosis fungoides-type cutaneous T-cell lymphoma. | Remove the use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Mechlorethamine | Polycythemia vera (palliative treatment) | 2018.10 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Omer Koc, MD Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP |
Although included in the manufacturer's labeling as a use, other contemporary therapies have replaced the use of mechlorethamine injection in the palliative management of polycythemia vera. Chronic myeloproliferative neoplasm guidelines do not include mechlorethamine as a treatment option for polycythemia vera (ESMO [Vannucchi 2015]). | Remove the use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Mitoxantrone | Breast cancer (metastatic) | 2018.12 (updated 2024.04) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Elizabeth Connor, MD Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP |
Limited (older) data exists for the use of mitoxantrone in the treatment of metastatic breast cancer; other established therapies have replaced the use of mitoxantrone for the treatment of metastatic breast cancer. | Remove the use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Pembrolizumab | Merkel cell carcinoma (advanced) | 2019.01 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Cabozantinib | Hepatocellular carcinoma (advanced) | 2019.01 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Pembrolizumab | Melanoma, stage III (adjuvant treatment) | 2019.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Atezolizumab | Small cell lung cancer (extensive-stage) | 2019.03 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Ado-trastuzumab emtansine | Breast cancer, early, HER2-positive (adjuvant therapy for residual disease) | 2019.05 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Ramucirumab | Hepatocellular carcinoma (advanced, relapsed/refractory) | 2019.05 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Vinblastine | Melanoma, metastatic (component of biochemotherapy) | 2019.09 (updated 2024.04) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP |
Although vinblastine has been previously used off-label as a component of the biochemotherapy regimen, CVD-interleukin-interferon (cisplatin, vinblastine, dacarbazine, aldesleukin, and interferon) for the treatment of metastatic melanoma, other contemporary therapies have replaced the use of this regimen in melanoma treatment. While combination biochemotherapy induced higher response rates and progression-free survival, this regimen did not improve overall survival or result in durable responses (Atkins 2008; Ives 2007). | Remove the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Cisplatin | Melanoma, metastatic (component of biochemotherapy) | 2019.09 (updated 2024.02) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Nick Link, PharmD, BCOP |
Although cisplatin has been previously used off-label as a component of the biochemotherapy regimen, CVD-interleukin-interferon (cisplatin, vinblastine, dacarbazine, aldesleukin, and interferon) for the treatment of metastatic melanoma, other contemporary therapies have replaced the use of this regimen in melanoma treatment. While combination biochemotherapy induced higher response rates and progression-free survival, this regimen did not improve overall survival or result in durable responses (Atkins 2008; Ives 2007). | Remove the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Olaparib | Pancreatic cancer, metastatic, BRCA-mutated (maintenance therapy) | 2020.01 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Interferon alfa-2b | Renal cell cancer, metastatic | 2020.01 (updated 2024.02) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, PharmD Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Although interferon alfa-2b has previously been used off-label and is included in combination with bevacizumab as a labeled use for bevacizumab (Avastin), other contemporary therapies have replaced the use of interferon in the management of renal cell cancer. Other therapies for the treatment of metastatic renal cell carcinoma have demonstrated improved response and survival compared to interferon alfas (ASCO [Rathmell 2022]). | Remove the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Interferon alfa-2b | Multiple myeloma | 2020.01 (updated 2024.02) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Nick Link, PharmD, BCOP Jordan Lundberg, PharmD, BCOP |
Although interferon alfa-2b has been previously used off label as maintenance therapy for multiple myeloma, other contemporary therapies have replaced the use of interferon in the management of multiple myeloma. Interferon alfa-2b is not included in ASCO/CCO guidelines for the treatment of multiple myeloma (ASCO/CCO [Mikhael 2019]). | Remove the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Luspatercept | Anemia due to lower-risk myelodysplastic syndromes with ring sideroblasts | 2020.04 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Encorafenib | Colorectal cancer, metastatic, refractory (RAS wild-type, BRAF V600E-mutant) | 2020.04 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Brigatinib | Non-small cell lung cancer, advanced (initial ALK-inhibitor therapy) | 2020.06 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Dexamethasone | Multiple myeloma | 2020.10 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
Hemady 20 mg tablet FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Fam-trastuzumab deruxtecan | Gastric cancer, advanced, previously treated (HER2-positive) | 2021.01 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Ipilimumab | Small cell lung cancer (progressive) | 2021.03 (updated 2024.03) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD Nick Link, PharmD, BCOP |
Although an early phase study suggested ipilimumab (in combination with nivolumab) may be of benefit in the treatment of progressive small cell lung cancer (after at least 1 platinum-based chemotherapy regimen), a confirmatory phase 3 trial did not demonstrate an overall survival benefit (Antonia 2016, Owonikoko 2021, Ready 2020). | Remove the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Ipilimumab | Melanoma, unresectable or metastatic, first-line combination therapy | 2021.06 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Lomustine | Hodgkin Lymphoma, progressive | 2021.06 (updated 2024.04) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP Klodiana Neme, PharmD, BCOP |
Although included as a labeled use in the Gleostine prescribing information, other contemporary therapies have replaced the use of lomustine in the treatment of progressive Hodgkin lymphoma. | Remove the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Pembrolizumab | Breast cancer (triple negative, early stage) | 2021.08 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | No Conflict of Interest No Conflict of Interest |
Zanubrutinib | Waldenström macroglobulinemia | 2021.09 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | No Conflict of Interest No Conflict of Interest |
Ruxolitinib | Graft-versus-host disease, treatment (chronic) | 2021.10 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | No Conflict of Interest No Conflict of Interest |
Cetuximab | Colorectal cancer, metastatic, refractory (RAS wild-type, BRAF V600E-mutant) | 2021.10 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | No Conflict of Interest No Conflict of Interest |
Binimetinib | Colorectal cancer, metastatic, refractory (RAS wild-type, BRAF V600E-mutant) | 2021.11 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Matthew Arango, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Omer Koc, MD |
Initial data from a phase 3 study suggested that binimetinib (in combination with encorafenib and cetuximab) was effective for the treatment of progressive metastatic RAS wild-type colorectal cancer in patients with BRAF V600E-mutant tumors (Van Cutsem 2019); however, an updated analysis demonstrated similar overall survival between the doublet regimen (cetuximab and encorafenib) and the triplet regimen (cetuximab, encorafenib, and binimetinib), while the triplet regimen was associated with a higher incidence of ≥ grade 3 adverse events (Tabernero 2021). | Remove the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Epirubicin | Esophageal cancer | 2022.01 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Matthew Arango, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP |
Evidence suggests a lack of support for this off-label use; other contemporary therapies have replaced the use of epirubicin for the treatment of esophageal cancer. | Remove the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Epirubicin | Gastric cancer | 2022.01 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Matthew Arango, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Klodiana Neme, PharmD, BCOP |
Evidence suggests a lack of support for this off-label use; other contemporary therapies have replaced the use of epirubicin for the treatment of gastric cancer. | Remove the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Epirubicin | Osteosarcoma | 2022.01 (updated 2024.04) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, Pharm D Nick Link PharmD, BCOP Jennifer Thackray, PharmD, BCPPS, BCPS |
Evidence suggests a lack of support for this off-label use; other established therapies have replaced the use of epirubicin for the treatment of osteosarcoma. | Remove the off-label use: 4 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Olaparib | Breast cancer, early, high risk, HER2-negative, germline BRCA-mutated, adjuvant therapy | 2022.03 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Fludarabine | Follicular lymphoma (relapsed/refractory) | 2022.07 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Mark Holdsworth, Pharm D Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP |
While fludarabine had been used off-label to treat relapsed or refractory follicular lymphoma, targeted therapies have replaced the use of fludarabine in the management of follicular lymphoma. | Remove the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Fam-trastuzumab deruxtecan | Non-small cell lung cancer, metastatic, relapsed/refractory, nonsquamous, HER2-mutant | 2022.08 | Diedra Bragalone, PharmD, BCOP, BCPS Jennifer Godden, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Durvalumab | Biliary tract cancer, advanced | 2022.09 | Diedra Bragalone, PharmD, BCOP, BCPS Jennifer Godden, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Carmustine injection | Multiple myeloma, palliative treatment | 2022.10 (updated 2024.03) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Mark Holdsworth, PharmD Lauren Ice, PharmD, BCPS, BCOP |
Although carmustine (injection) is approved for the palliative treatment of multiple myeloma (in combination with prednisone), other contemporary therapies have replaced IV carmustine for palliative treatment of multiple myeloma. | Remove the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Carmustine injection | Non-Hodgkin lymphoma, relapsed or refractory, palliative treatment | 2022.10 (updated 2024.03) | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP Angela German, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Jordan Lundberg, PharmD, BCOP |
Although carmustine (injection) is approved for the palliative treatment (secondary) of non-Hodgkin lymphoma (in combination with other antineoplastics) that has relapsed with or was refractory to primary therapy, other contemporary therapies have replaced IV carmustine for treatment of relapsed or refractory non-Hodgkin lymphoma. | Remove the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Mitomycin (systemic) | Esophageal cancer, advanced | 2022.11 | Stephanie Minich, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Matthew Arango, PharmD, BCOP Polly Kintzel, PharmD, BCOP, BCPS Angela German, PharmD, BCOP |
Evidence suggests a lack of support for this off-label use; other contemporary therapies have replaced the use of mitomycin (systemic) for the treatment of advanced esophageal cancer. | Remove the off-label use: 5 of 5 | No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest No Conflict of Interest |
Capecitabine | Esophageal, gastric, and gastroesophageal cancers | 2023.01 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Capecitabine | Pancreatic cancer, potentially curable, adjuvant therapy | 2023.01 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Zanubrutinib | Chronic lymphocytic leukemia, relapsed or refractory | 2023.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Sacituzumab govitecan | Breast cancer, metastatic, hormone receptor-positive, HER2-negative, salvage therapy | 2023.02 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Polatuzumab vedotin | Diffuse large B-cell lymphoma, intermediate or high-risk, previously untreated | 2023.05 | Diedra Bragalone, PharmD, BCOP, BCPS Stephanie Minich, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Pirtobrutinib | Chronic lymphocytic leukemia/small lymphocytic lymphoma, relapsed or refractory | 2023.12 | Angela German, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS |
FDA approved (no panel vote needed – removed from off-label uses due to approval by FDA). | n/a | n/a |
Fam-trastuzumab deruxtecan | Colorectal cancer, metastatic, HER2-expressing | 2024.04 | Angela German, PharmD, BCOP Diedra Bragalone, PharmD, BCOP, BCPS Matthew Arango, PharmD, BCOP |
FDA approved (no panel vote needed – removed from off-label uses due to approval [in solid tumors] by FDA). | n/a | n/a |
Last update August 2, 2024