HealthJuly 23, 2024

Cross-tapering mental health medications is now the PCP’s responsibility

An increase in mental health care needs has led to primary care physicians navigating the complex challenges of mental health medication management

In recent years, the healthcare industry has seen a shift of mental health management from the specialist realm to primary care as mental health issues become more prevalent.

Between 2007 and 2017, the percentage of behavioral health-associated medical claims doubled, while outpatient spending on psychiatry grew by 40%. These trends have been exacerbated by the COVID-19 pandemic. RAND reports that spending on mental health services jumped 53% between March 2020 and August 2022 among people with employer-provided insurance. In that same period, use of mental health services grew by 39%. As these issues in mental and behavioral health continue to progress, primary care providers will need tools that support their ever-expanding roles in the health of their patients.

A shortage in mental health professionals is also impacting these challenges. Fewer than half of people experiencing mental illness in 2021 were able to access timely care. Those who struggled the most were people in rural areas, people covered by Medicaid, and underserved groups (non-English speakers, people of color, and LGBTQ communities).

This shortage has shifted much of mental health care challenges and mental health medication management to primary care providers, including one of the most complex areas of mental health medication management, cross-tapering mental health medications. Over 70% of primary care providers are writing an initial prescription for anxiety or depression for at least one patient a week. A full 85% are providing long-term mental health care for the same proportion.

The result is that these providers are expected to squeeze in complex mental health needs and mental health medication management tasks like cross-tapering on top of other responsibilities, including preventive care, medication history review, social determinants of health assessments, visit documentation, and health counseling.

The cross-tapering process explained

Cross-tapering is a process of switching a patient from one medication to another. Often used with antidepressants, it involves gradually reducing and stopping one antidepressant while simultaneously introducing and increasing the dose of a second. It most commonly involves the following steps:

  • Assess patient history
  • Determine tapering plan
  • Monitor the patient closely
  • Educate the patient on their treatment
  • Adjust medications based on symptoms and provider observations

The difficulty of cross-tapering mental health medications

Mental health care is a complex responsibility.  While primary care providers are familiar with recommending first or even second line drugs to patients, switching a patient’s medication requires specialist-level understanding of drug interactions, contraindications and side effects, and pharmacotherapy risk management.

Antidepressants carry a high rate of discontinuation symptoms, including a risk of antidepressant discontinuation syndrome (ADS), which is characterized by flu-like symptoms, dizziness, mood disturbances, insomnia, and more. Many of these issues can be mitigated with support for cross-tapering including patient education and identification of high-risk patients, but this puts yet another responsibility on the shoulders of PCPs—over 80% of primary care providers (PCPs) report finding cross-tapering for mental health medications somewhat to extremely difficult.

The impact of switching prescribed antidepressants

When treating patients with depression, only around 50% of patients have been found to respond to the first antidepressant prescribed, meaning they then need to switch to another.

Cross-tapering is often preferred as a switching strategy since it avoids a break in treatment and patients can benefit from combination therapy during the crossover period. But this approach can lead to an increase in side effects. Patients must be closely monitored for symptoms such as serotonin syndrome whenever more than one serotonergic agent is being used and especially in the case of comorbidities and other medications. Different mental health conditions, including depression, anxiety, bipolar disorder and schizophrenia all require tailored approaches and have condition-specific guidelines.

Tools and resources for cross-tapering mental health medications

Current solutions around cross-tapering include hiring more mental health specialists to relieve the burden on primary care providers in mental health. But for smaller practices, this might not be feasible. PCPs should be encouraged to explore collaborative care programs and refer out when possible to close gaps in care. Individuals and small practices should also consider specific tools to improve their cross-tapering results and support positive outcomes for their patients.

  • Clinical decision support systems: Implementing tools that provide guidance on drug interactions and tapering schedules.
  • Patient engagement solutions: Using platforms that enhance patient communication and adherence.
  • Drug interaction databases: Accessing reliable databases to check for contraindications and side effects.

Primary care physicians should look for strategies to increase their knowledge of cross-tapering with tools like clinical decision support resources, patient engagement solutions, and referential drug data  to support them in tasks like understanding interactions between antidepressants and other medications. These actions are the starting point for maintaining positive results as the PCP’s role continues to expand into the mental health sphere.

UpToDate supports a simplified medication management process with the newly available Rx Transitions for Mental Health tool. With a printable switching schedule and critical information on dosing and side effects, this interactive tool offers efficient and trusted step-by-step guidance for switching antidepressant prescriptions. This valuable upgrade is available for an additional fee with an individual UpToDate Pro subscription. Unlike other switching tools, Rx Transitions for Mental Health is embedded into the clinician’s existing medical reference workflow and the guidance is established and maintained by the leading UpToDate clinical editorial team.

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