Make real-time clinical decisions based on the most current evidence
When you’re treating a patient, you want to make decisions based on the best available evidence and expertise. But even the most experienced clinicians need support in keeping up with new research and advances in care.
UpToDate authors and editors synthesize the available clinical evidence and best clinical practices to help you provide high-quality care to your patients and high standards of research.
We follow a systematic and transparent editorial policy for identifying, reviewing, and synthesizing clinical evidence as it applies to a clinical question
To create and update the clinical topics in UpToDate, our editorial staff performs comprehensive reviews of the medical literature and considers the quality of the study, the hierarchy of evidence, and its clinical relevance.
At the top of the evidence hierarchy are meta-analyses or randomized trials of high methodological quality, followed by randomized trials with methodological limitations, then observational studies and unsystematic clinical observations (expert consensus or opinions). Inferences are stronger when the evidence is summarized in systematic reviews that present all relevant data.